Profiling of Sea Urchin Extracts From Lombok for Evidence-Based Natural Therapeutics

Abstract

The marine ecosystems of Lombok, Indonesia, represent a rich, yet largely untapped, reservoir of biodiversity with significant potential for novel drug discovery. Sea urchins (Echinoidea) are known to synthesize a diverse array of bioactive secondary metabolites, many of which exhibit promising pharmacological activities. This paper outlines a comprehensive strategy for the systematic profiling of sea urchin extracts from selected species found in Lombok's coastal waters. The methodology encompasses ethical sample collection, meticulous species identification, optimized extraction procedures, and advanced analytical techniques (LC-MS/MS, GC-MS, NMR) for chemical characterization. Furthermore, a battery of in vitro bioassays will be employed to evaluate potential therapeutic properties, including antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activities. The overarching aim is to establish a robust scientific evidence base for the traditional and potential new uses of Lombok's sea urchins in natural therapeutics. This research is pivotal for valorizing local marine bioresources, guiding future bioprospecting efforts, and contributing to the development of standardized, safe, and effective natural medicines, while also informing conservation strategies